Getting the First Grant

First things first: getting primary care right.

G IVEN THE BROAD AGENDA, HIGH EXPECtations , increasing patient complexity, growing evidence base, intensifying threats to provider work dissatisfaction , and the worsening workforce shortage of primary care physicians, there is an urgent need to fix the problems of primary care. Primary care has been marginalized, and our own professional societies have encountered numerous obstacles in advoca...

ESC First Contact Initiative Grant - Report

Getting it right the first time.

In this issue of the AJNR, Theron et al. [1] report on a retrospective analysis of carotid angioplasty in 13 patients in whom a modification of a previously described catheter system designed to protect the cerebral circulation during the procedure was used. The temporary arrest of flow within the internal carotid artery and flushing of the arterial segment proximal to the temporary occlusion b...

Getting Nanotechnology Right the First Time

Thank you for this opportunity to offer the perspective of Environmental Defense to this panel. Environmental Defense, formerly known as Environmental Defense Fund, was established in 1967 by scientists who were among the first to discern the devastating effects of aerial spraying of DDT on wildlife. Today, Environmental Defense is one of the country's leading environmental advocacy organizatio...

Getting to First Base in Proteasome Assembly

Assembly of complex structures such as the eukaryotic 26S proteasome requires intricate mechanisms that ensure precise subunit arrangements. Recent studies have shed light on the pathway for ordered assembly of the base of the 19S regulatory particle of the 26S proteasome by identifying new precursor complexes and four dedicated chaperones involved in its assembly.